:root {
      --ink: #17324d;
      --muted: #5c7083;
      --blue: #087da7;
      --blue-dark: #075d81;
      --blue-pale: #edf8fc;
      --teal: #138d9a;
      --teal-dark: #0b6870;
      --teal-pale: #eef8f7;
      --teal-line: #b8dbd9;
      --line: #dce8ee;
      --white: #ffffff;
      --shadow: 0 18px 48px rgba(17, 67, 91, .12);
    }

    * { box-sizing: border-box; }

    html { scroll-behavior: smooth; }

    body {
      margin: 0;
      color: var(--ink);
      background: #f7fbfd;
      font-family: Arial, Helvetica, sans-serif;
      line-height: 1.6;
    }

    a { color: inherit; }

    a:focus-visible {
      outline: 3px solid #f3bf45;
      outline-offset: 4px;
      border-radius: 4px;
    }

    .wrap {
      width: min(1120px, calc(100% - 40px));
      margin-inline: auto;
    }

    .site-header {
      position: sticky;
      top: 0;
      z-index: 1000;
      background: var(--white);
      border-bottom: 1px solid var(--line);
      box-shadow: 0 5px 18px rgba(17,67,91,.08);
    }

    .header-inner {
      min-height: 84px;
      display: flex;
      align-items: center;
      justify-content: space-between;
      gap: 28px;
    }

    .brand { display: inline-flex; align-items: center; color: var(--ink); text-decoration: none; }
    .brand-wordmark { color: var(--ink); font-family: Arial, Helvetica, sans-serif; font-size: clamp(1.35rem,2.6vw,1.78rem); font-weight: 850; letter-spacing: -.045em; line-height: 1; }
    .brand-domain { color: var(--blue); }

    .site-nav {
      display: flex;
      flex-wrap: wrap;
      gap: 9px 15px;
      align-items: center;
    }

    .site-nav > a, .nav-group summary {
      color: var(--blue-dark);
      font-size: .86rem;
      font-weight: 700;
      line-height: 1.35;
      text-decoration: none;
    }

    .site-nav > a:hover, .nav-group summary:hover { text-decoration: underline; }
    .nav-group { position: relative; }
    .nav-group summary { display: flex; gap: 7px; align-items: center; cursor: pointer; list-style: none; }
    .nav-group summary::-webkit-details-marker { display: none; }
    .nav-group summary::after { width: 6px; height: 6px; margin-top: -3px; border-right: 2px solid currentColor; border-bottom: 2px solid currentColor; content: ""; transform: rotate(45deg); transition: transform .16s ease; }
    .nav-group[open] summary::after { margin-top: 3px; transform: rotate(225deg); }
    .nav-dropdown { position: absolute; z-index: 1200; top: calc(100% + 13px); left: -16px; display: grid; width: 290px; padding: 10px 16px; border: 1px solid var(--line); border-radius: 14px; background: #fff; box-shadow: 0 18px 42px rgba(17,67,91,.16); }
    .nav-group-endocrine .nav-dropdown { width: 330px; }
    .nav-group-immune .nav-dropdown { width: 300px; }
    .nav-group-more .nav-dropdown { right: -10px; left: auto; }
    .nav-dropdown::before { position: absolute; top: -7px; left: 24px; width: 12px; height: 12px; border-top: 1px solid var(--line); border-left: 1px solid var(--line); background: #fff; content: ""; transform: rotate(45deg); }
    .nav-group-more .nav-dropdown::before { right: 26px; left: auto; }
    .nav-dropdown a { position: relative; z-index: 1; padding: 9px 2px; border-bottom: 1px solid #e4edf1; color: var(--blue-dark); font-size: .82rem; font-weight: 750; line-height: 1.35; text-decoration: none; }
    .nav-dropdown a:last-child { border-bottom: 0; }
    .nav-dropdown a:hover, .nav-dropdown a:focus-visible { color: var(--ink); text-decoration: underline; }

    .eyebrow {
      margin: 0 0 12px;
      color: var(--blue);
      font-size: .78rem;
      font-weight: 800;
      letter-spacing: .13em;
      text-transform: uppercase;
    }

    h1, h2, h3 { line-height: 1.18; }

    h1 {
      max-width: 760px;
      margin: 0;
      font-size: clamp(2.25rem, 5vw, 4.6rem);
      letter-spacing: -.045em;
    }

    main section { padding: 68px 0; }

    .section-heading {
      max-width: 680px;
      margin-bottom: 30px;
    }

    h2 {
      margin: 0;
      font-size: clamp(1.65rem, 3vw, 2.45rem);
      letter-spacing: -.025em;
    }

    .section-heading p {
      margin: 12px 0 0;
      color: var(--muted);
    }

    .cards {
      display: grid;
      grid-template-columns: repeat(2, minmax(0, 1fr));
      gap: 18px;
    }

    .card {
      min-height: 176px;
      padding: 24px;
      border: 1px solid var(--line);
      border-radius: 18px;
      background: var(--white);
      box-shadow: 0 8px 24px rgba(17, 67, 91, .06);
      text-decoration: none;
      transition: transform .18s ease, border-color .18s ease, box-shadow .18s ease;
    }

    .card:hover {
      transform: translateY(-3px);
      border-color: #9bcfdf;
      box-shadow: var(--shadow);
    }

    .card h3 {
      margin: 0 0 8px;
      color: var(--blue-dark);
      font-size: 1.08rem;
    }

    .card p {
      margin: 0;
      color: var(--muted);
      font-size: .94rem;
    }

    .pillars { background: #fff; border-block: 1px solid var(--line); }
    .pillar-card { min-height: 218px; }
    .pillar-card .eyebrow { margin-bottom: 8px; }
    .pillar-card strong { display: inline-block; margin-top: 18px; color: var(--blue-dark); }
    .topic-route { border-top: 1px solid var(--line); }
    .topic-route:nth-of-type(even) { background: #fff; }
    .topic-route-grid { display: grid; grid-template-columns: repeat(3,minmax(0,1fr)); gap: 14px; margin: 28px 0 0; padding: 0; list-style: none; }
    .topic-route-card { --accent:#168db3; position: relative; display: grid; grid-template-columns: 38px minmax(0,1fr); gap: 7px 13px; min-height: 158px; padding: 20px; border: 1px solid var(--line); border-top: 4px solid var(--accent); border-radius: 14px; color: var(--ink); background: #fff; box-shadow: 0 8px 22px rgba(17,67,91,.06); text-decoration: none; transition: transform .16s ease,border-color .16s ease,box-shadow .16s ease; }
    .topic-route-card:hover { transform: translateY(-3px); border-color: var(--accent); box-shadow: 0 13px 30px rgba(17,67,91,.1); }
    .topic-route-number { display: grid; grid-row: 1/4; width: 34px; height: 34px; place-items: center; border-radius: 50%; color: #fff; background: var(--accent); font-size: .76rem; font-weight: 900; }
    .topic-route-card small,.topic-route-card strong,.topic-route-card span { display: block; }
    .topic-route-card small { color: var(--accent); font-size: .67rem; font-weight: 900; letter-spacing: .08em; text-transform: uppercase; }
    .topic-route-card strong { font-size: 1.02rem; line-height: 1.3; }
    .topic-route-card .topic-route-description { color: var(--muted); font-size: .82rem; line-height: 1.5; }
    .topic-route-card b { grid-column: 2; align-self: end; color: var(--accent); font-size: .75rem; }
    .route-subheading { max-width: 780px; margin: 34px 0 0; }
    .route-subheading h3 { margin: 0 0 8px; color: var(--ink); font-size: clamp(1.25rem,2.4vw,1.62rem); }
    .route-subheading p { margin: 0; color: var(--muted); line-height: 1.65; }
    .endocrine-foundation-heading { margin-top: 26px; }
    .endocrine-foundation-grid,.endocrine-gland-grid { margin-top: 18px; }
    .endocrine-gland-heading { margin-top: 42px; padding-top: 30px; border-top: 1px solid #cadfd9; }
    .route-endocrine .topic-route-card { --accent:#2f8d91; }
    .endocrine-gland-grid { grid-template-columns: repeat(4,minmax(0,1fr)); }
    .endocrine-gland-grid .topic-route-card { min-height: 148px; padding: 17px 18px; grid-template-columns: 32px minmax(0,1fr); gap: 6px 10px; }
    .endocrine-gland-grid .topic-route-number { width: 30px; height: 30px; }
    .endocrine-gland-grid .topic-route-description { font-size: .78rem; line-height: 1.45; }
    .route-endocrine .endo-home-organs--compact { margin-top: 34px; padding-top: 24px; border-top: 1px solid #cadfd9; }
    .route-endocrine .endo-home-organs--compact h3 { margin: 0 0 7px; color: var(--ink); font-size: clamp(1.08rem,2vw,1.3rem); }
    .route-endocrine .endo-home-organs--compact p { margin: 0; color: var(--muted); line-height: 1.6; }
    .endo-inline-links { display: grid; grid-template-columns: repeat(4,minmax(0,1fr)); gap: 0 22px; margin-top: 14px; }
    .endo-inline-links a { display: flex; min-height: 42px; align-items: center; justify-content: space-between; gap: 10px; border-bottom: 1px solid #d2e3df; color: var(--blue-dark); font-size: .88rem; font-weight: 780; text-decoration: none; }
    .endo-inline-links a::after { content: "→"; flex: 0 0 auto; color: var(--teal-dark); }
    .endo-inline-links a:hover,.endo-inline-links a:focus-visible { color: var(--teal-dark); border-color: var(--teal-line); }
    .route-stem { background: #f7fbfd; }
    .route-endocrine { background: #fff; }
    .route-nervous { background: #f5f7fb; }
    .route-immune { background: #f3faf7; }
    .route-nervous .topic-route-card { --accent:#5d77aa; }
    .route-immune .topic-route-card { --accent:#358a75; }

    .site-footer { position: relative; overflow: hidden; padding: 54px 0 28px; border-top: 1px solid #bfd3de; color: var(--muted); background: linear-gradient(145deg,#e7f1f5 0%,#d7e7ef 100%); font-size: .88rem; }
        .footer-content { position: relative; z-index: 1; display: grid; grid-template-columns: minmax(240px,1fr) minmax(320px,1.25fr); gap: 30px 56px; align-items: start; }
    .footer-brand strong { display: block; margin-bottom: 8px; color: var(--ink); font-size: 1.35rem; letter-spacing: -.025em; }
    .footer-brand p { max-width: 420px; margin: 0; line-height: 1.6; }
.footer-topic { white-space: nowrap; }
.footer-brand .footer-advice { display: flex; align-items: center; gap: 8px; margin-top: 10px; color: var(--ink); font-size: .84rem; font-weight: 700; line-height: 1.4; }
.footer-advice svg { width: 17px; height: 17px; flex: 0 0 auto; color: var(--teal-dark); }
    .footer-links { display: flex; flex-wrap: wrap; justify-content: flex-end; gap: 11px 24px; padding-top: 6px; }
    .footer-links a { color: var(--blue-dark); font-weight: 750; text-decoration: none; }
    .footer-links a:hover,.footer-links a:focus-visible { text-decoration: underline; }
    .footer-copy { grid-column: 1/-1; display: flex; flex-wrap: wrap; justify-content: space-between; gap: 10px 24px; margin: 0; padding-top: 21px; border-top: 1px solid rgba(157,193,207,.55); font-size: .78rem; }
    .footer-copy span { color: #526d7b; }

    @media (max-width: 850px) {
      .header-inner { align-items: flex-start; padding: 18px 0; }
      .header-inner { flex-direction: column; }
      .footer-content { grid-template-columns: 1fr; gap: 24px; }
      .footer-links { justify-content: flex-start; }
          .cards { grid-template-columns: repeat(2, minmax(0, 1fr)); }
      .topic-route-grid { grid-template-columns: repeat(2,minmax(0,1fr)); }
      .endo-inline-links { grid-template-columns: repeat(2,minmax(0,1fr)); }
      .site-nav { width: 100%; }
      .nav-dropdown { width: min(330px,calc(100vw - 42px)); }
    }

    @media (max-width: 560px) {
      .wrap { width: min(100% - 28px, 1120px); }
      .site-nav { gap: 9px 12px; }
      .nav-group { flex: 1 1 calc(50% - 12px); }
      .nav-group[open] { flex-basis: 100%; }
      .nav-group summary { min-height: 36px; }
      .nav-dropdown,.nav-group-endocrine .nav-dropdown,.nav-group-immune .nav-dropdown,.nav-group-more .nav-dropdown { position: static; width: 100%; margin-top: 8px; }
      .nav-dropdown::before { display: none; }
      .site-nav > a { flex: 1 1 calc(50% - 12px); }
      main section { padding: 52px 0; }
      .cards { grid-template-columns: 1fr; }
      .topic-route-grid { grid-template-columns: 1fr; }
      .endo-inline-links { grid-template-columns: 1fr; }
      .card { min-height: auto; }
    }
    .brand { flex-shrink: 0; max-width: 100%; }
    .brand-logo-frame { display: block; flex: 0 0 auto; width: 228px; max-width: 100%; aspect-ratio: 1422 / 338; }
    .brand-logo-frame img { display: block; width: 100%; max-width: 100%; height: auto; }
    /* Het compacte v74-logo heeft geen verborgen witruimte en hoeft niet te worden bijgesneden. */
    .footer-logo { display: inline-block; max-width: 100%; margin-bottom: 8px;  }
    .footer-logo .brand-logo-frame { width: 248px; }
    /* Subtiele blauwgroene merkaccenten; de blauwe basis blijft behouden. */
    .brand-domain { color: var(--teal); }
    .eyebrow,
    .section-heading .eyebrow,
    .pillar-card .eyebrow,
    .gland-card .gland-card-kicker,
    .fact-strip small,
    .search-result-meta { color: var(--teal-dark); }
    .site-nav > a:hover,
    .nav-group > summary:hover,
    .nav-group[open] > summary,
    .nav-group.is-active > summary,
    .site-nav > a[aria-current="page"],
    .nav-dropdown a:hover,
    .nav-dropdown a:focus-visible { color: var(--teal-dark); }
    .nav-dropdown a[aria-current="page"] { color: var(--teal-dark); background: var(--teal-pale); box-shadow: 8px 0 0 var(--teal-pale),-8px 0 0 var(--teal-pale); }
    .article-content a:hover,
    .side-card a:hover,
    .directory-card a:hover,
    .breadcrumbs a:hover,
    .footer-links a:hover,
    .footer-links a:focus-visible,
    .gland-card-link { color: var(--teal-dark); }
    .pillar-card strong { color: var(--teal-dark); }
    .card:hover,
    .gland-card:hover,
    .article-next a:hover,
    .gland-next a:hover { border-color: var(--teal-line); }
    .direct-answer,
    .research-bridge,
    .about-value,
    .search-result-card { border-left-color: var(--teal); }
    .faq-list details[open] { border-color: var(--teal-line); }
    .faq-list details[open] > summary { color: var(--teal-dark); background: var(--teal-pale); }
    .faq-item summary::after { color: var(--teal-dark); }
    .form-field input:focus,
    .form-field select:focus,
    .form-field textarea:focus,
    .search-input-row input:focus { outline-color: rgba(19,141,154,.22); border-color: var(--teal-dark); }
    .form-consent input { accent-color: var(--teal-dark); }
    .site-footer { border-top-color: var(--teal-line); background: radial-gradient(ellipse at 100% 0%,rgba(19,141,154,.10),transparent 62%),linear-gradient(145deg,#e7f1f5 0%,#d7e7ef 100%); }