/* Rustige, geordende hoofdnavigatie voor Stamcel.org v64. */
.site-header.menu-v64-ready {
  border-bottom-color: #d5e4e9;
  background: rgba(255,255,255,.985);
  box-shadow: 0 4px 16px rgba(17,67,91,.07);
}

@media (min-width: 1101px) {
  .site-header.menu-v64-ready .header-inner {
    position: relative;
    min-height: 72px;
    gap: 10px;
  }

  .site-header.menu-v64-ready .brand {
    margin-right: auto;
  }

  .site-header.menu-v64-ready .brand-logo-frame {
    width: 174px;
  }

  .site-header.menu-v64-ready .site-nav {
    flex-wrap: nowrap;
    gap: 1px;
  }

  .site-header.menu-v64-ready .nav-group {
    position: static;
  }

  .site-header.menu-v64-ready .site-nav > a,
  .site-header.menu-v64-ready .nav-group > summary {
    min-height: 44px;
    padding: 11px 8px;
    border-radius: 8px;
    color: #21495c;
    font-size: .84rem;
    font-weight: 700;
    text-decoration: none;
    transition: color .16s ease, background-color .16s ease;
  }

  .site-header.menu-v64-ready .site-nav > a:hover,
  .site-header.menu-v64-ready .site-nav > a:focus-visible,
  .site-header.menu-v64-ready .nav-group > summary:hover,
  .site-header.menu-v64-ready .nav-group > summary:focus-visible {
    color: #123f54;
    background: #eef7f8;
    text-decoration: none;
  }

  .site-header.menu-v64-ready .nav-group[open] > summary,
  .site-header.menu-v64-ready .nav-group.is-active > summary {
    color: #0b6870;
    background: #edf7f5;
  }

  .site-header.menu-v64-ready .nav-group > summary::after {
    width: 7px;
    height: 7px;
    margin-left: 1px;
    border-width: 1.5px;
  }

  .site-header.menu-v64-ready .nav-group > summary:focus {
    outline: 0;
  }

  .site-header.menu-v64-ready .nav-group > summary:focus-visible {
    outline: 2px solid #78b9b4;
    outline-offset: 2px;
  }

  .site-header.menu-v64-ready .site-search-nav {
    width: 44px;
    min-width: 44px;
    padding: 10px;
  }

  .site-header.menu-v64-ready .menu-contact-link {
    margin-left: 4px;
    padding-inline: 13px;
    border: 1px solid #c7dce3;
    background: #fff;
  }

  .site-header.menu-v64-ready .nav-dropdown,
  .site-header.menu-v64-ready .nav-group-endocrine .nav-dropdown,
  .site-header.menu-v64-ready .nav-group-immune .nav-dropdown,
  .site-header.menu-v64-ready .nav-group-more .nav-dropdown {
    position: absolute;
    z-index: 1200;
    top: calc(100% + 8px);
    right: 8px;
    left: 8px;
    display: grid;
    grid-template-columns: minmax(190px,.72fr) minmax(0,2fr);
    width: auto;
    max-height: min(72vh,660px);
    margin: 0;
    padding: 0;
    overflow-y: auto;
    border: 1px solid #d5e4e9;
    border-radius: 14px;
    background: #fff;
    box-shadow: 0 18px 42px rgba(17,67,91,.13);
    transform: translateY(0);
    transform-origin: top center;
    animation: menu-v64-open .18s ease-out;
  }

  .site-header.menu-v64-ready .nav-dropdown::before {
    display: none;
  }

  .site-header.menu-v64-ready .menu-mega-intro {
    padding: 23px 22px 25px;
    border-right: 1px solid #dce8ee;
    background: #f5fafb;
  }

  .site-header.menu-v64-ready .menu-mega-intro h2 {
    margin: 0 0 8px;
    color: #17324d;
    font-size: 1.17rem;
    font-weight: 760;
    line-height: 1.25;
  }

  .site-header.menu-v64-ready .menu-mega-intro p {
    margin: 0 0 15px;
    color: #5c7083;
    font-size: .86rem;
    line-height: 1.55;
  }

  .site-header.menu-v64-ready .menu-mega-intro a {
    display: inline-flex;
    min-height: 0;
    padding: 3px 0;
    border: 0;
    color: #0b6870;
    font-size: .86rem;
    font-weight: 700;
  }

  .site-header.menu-v64-ready .menu-mega-columns {
    display: grid;
    grid-template-columns: repeat(var(--menu-column-count,2),minmax(0,1fr));
    gap: 22px;
    padding: 23px 24px 26px;
  }

  .site-header.menu-v64-ready .menu-mega-column h3 {
    margin: 0 0 7px;
    color: #647887;
    font-size: .74rem;
    font-weight: 700;
    letter-spacing: .06em;
    line-height: 1.35;
    text-transform: uppercase;
  }

  .site-header.menu-v64-ready .menu-mega-column a {
    display: block;
    min-height: 0;
    padding: 7px 0;
    border: 0;
    color: #21495c;
    font-size: .85rem;
    font-weight: 600;
    line-height: 1.35;
    text-decoration: none;
  }

  .site-header.menu-v64-ready .menu-mega-column a:hover,
  .site-header.menu-v64-ready .menu-mega-column a:focus-visible {
    color: #0b6870;
    text-decoration: underline;
    text-underline-offset: 3px;
  }

  .site-header.menu-v64-ready .menu-mega-column a[aria-current="page"],
  .site-header.menu-v64-ready .menu-mega-intro a[aria-current="page"] {
    color: #17324d;
    background: transparent;
    box-shadow: none;
    text-decoration: underline;
    text-decoration-color: #54a99a;
    text-decoration-thickness: 2px;
    text-underline-offset: 4px;
  }
}

@media (max-width: 1100px) {
  .site-header.menu-v64-ready .header-inner {
    min-height: 68px;
    padding-block: 10px;
  }

  .site-header.menu-v64-ready .mobile-search,
  .site-header.menu-v64-ready .mobile-menu-toggle {
    border-color: transparent;
    background: transparent;
  }

  .site-header.menu-v64-ready .mobile-search:hover,
  .site-header.menu-v64-ready .mobile-search:focus-visible,
  .site-header.menu-v64-ready .mobile-menu-toggle:hover,
  .site-header.menu-v64-ready .mobile-menu-toggle:focus-visible,
  .site-header.menu-v64-ready .mobile-menu-toggle[aria-expanded="true"] {
    background: #edf7f5;
  }

  .site-header.menu-v64-ready .mobile-menu-toggle {
    gap: 7px;
  }

  .site-header.menu-v64-ready .menu-hamburger {
    display: inline-grid;
    width: 17px;
    gap: 3px;
  }

  .site-header.menu-v64-ready .menu-hamburger i {
    display: block;
    height: 1.5px;
    border-radius: 2px;
    background: currentColor;
  }

  .site-header.menu-v64-ready.mobile-menu-open .site-nav {
    padding: 8px 20px 22px;
    border-right: 0;
    border-left: 0;
    border-bottom-color: #d5e4e9;
    background: #fff;
    box-shadow: 0 18px 30px rgba(17,67,91,.13);
  }

  .site-header.menu-v64-ready .site-nav details {
    border-bottom-color: #e4edef;
  }

  .site-header.menu-v64-ready .site-nav > a,
  .site-header.menu-v64-ready .site-nav summary {
    min-height: 48px;
    padding: 13px 5px;
    color: #21495c;
    font-size: .96rem;
    text-decoration: none;
  }

  .site-header.menu-v64-ready .site-nav summary {
    display: flex;
    width: 100%;
    flex: 1 1 auto;
    align-items: center;
    justify-content: space-between;
    gap: 12px;
  }

  .site-header.menu-v64-ready .site-nav summary::after {
    flex: 0 0 7px;
    margin-right: 5px;
    margin-left: auto;
  }

  .site-header.menu-v64-ready .site-nav details[open] > summary {
    color: #0b6870;
  }

  .site-header.menu-v64-ready .site-nav .nav-dropdown,
  .site-header.menu-v64-ready .site-nav details[open] > .nav-dropdown {
    display: grid;
    width: 100%;
    margin: 0 0 12px;
    padding: 0;
    overflow: hidden;
    border: 1px solid #dce8ee;
    border-radius: 10px;
    background: #f7fbfb;
  }

  .site-header.menu-v64-ready .menu-mega-intro {
    padding: 15px 16px 13px;
    border-bottom: 1px solid #dce8ee;
  }

  .site-header.menu-v64-ready .menu-mega-intro h2 {
    margin: 0 0 5px;
    font-size: 1.05rem;
  }

  .site-header.menu-v64-ready .menu-mega-intro p {
    margin: 0 0 7px;
    color: #5c7083;
    font-size: .86rem;
    line-height: 1.5;
  }

  .site-header.menu-v64-ready .menu-mega-intro a,
  .site-header.menu-v64-ready .menu-mega-column a {
    min-height: 44px;
    padding: 10px 8px;
    border: 0;
    color: #21495c;
    font-size: .9rem;
  }

  .site-header.menu-v64-ready .menu-mega-columns {
    display: grid;
    grid-template-columns: 1fr;
    gap: 12px;
    padding: 13px 8px 16px;
  }

  .site-header.menu-v64-ready .menu-mega-column h3 {
    margin: 0;
    padding: 0 8px 2px;
    color: #647887;
    font-size: .73rem;
    letter-spacing: .055em;
    text-transform: uppercase;
  }

  .site-header.menu-v64-ready .menu-contact-link {
    margin-top: 4px;
    font-weight: 700;
  }
}

@media (max-width: 380px) {
  .site-header.menu-v64-ready .brand-logo-frame {
    width: 142px;
  }
}

@media (prefers-reduced-motion: reduce) {
  .site-header.menu-v64-ready .nav-dropdown {
    animation: none;
  }
}

@keyframes menu-v64-open {
  from { opacity: 0; transform: translateY(-5px); }
  to { opacity: 1; transform: translateY(0); }
}


/* De eerste kaart is zelf de koppeling naar de hoofdpagina. */
.site-header.menu-v64-ready a.menu-mega-intro {
  display: block;
  color: inherit;
  text-decoration: none;
  cursor: pointer;
  transition: background-color .16s ease, box-shadow .16s ease;
}

.site-header.menu-v64-ready a.menu-mega-intro:hover,
.site-header.menu-v64-ready a.menu-mega-intro:focus-visible {
  color: inherit;
  background: #eaf5f5;
  box-shadow: inset 0 0 0 2px #78b9b4;
  text-decoration: none;
  outline: 0;
}

.site-header.menu-v64-ready .menu-mega-kicker {
  display: block;
  margin-bottom: 7px;
  color: #5d7481;
  font-size: .72rem;
  font-weight: 800;
  letter-spacing: .075em;
  line-height: 1.3;
  text-transform: uppercase;
}

.site-header.menu-v64-ready .menu-mega-action {
  display: inline-flex;
  min-height: 36px;
  align-items: center;
  margin-top: 2px;
  padding: 8px 12px;
  border-radius: 8px;
  background: #0b6870;
  color: #fff;
  font-size: .84rem;
  font-weight: 750;
  line-height: 1.25;
}

.site-header.menu-v64-ready a.menu-mega-intro[aria-current="page"] {
  background: #edf7f5;
  box-shadow: inset 4px 0 0 #54a99a;
}

.site-header.menu-v64-ready a.menu-mega-intro[aria-current="page"] .menu-mega-action {
  border: 1px solid #9bc8c2;
  background: #fff;
  color: #315d63;
}

@media (min-width: 1101px) {
  .site-header.menu-v64-ready a.menu-mega-intro {
    min-width: 0;
  }

  .site-header.menu-v64-ready .menu-mega-kicker {
    font-size: .70rem;
    font-weight: 750;
  }

  .site-header.menu-v64-ready .menu-mega-action {
    font-size: .82rem;
    font-weight: 700;
  }
}

@media (max-width: 1100px) {
  .site-header.menu-v64-ready a.menu-mega-intro {
    padding: 16px;
  }

  .site-header.menu-v64-ready .menu-mega-kicker {
    margin-bottom: 5px;
    font-size: .69rem;
  }

  .site-header.menu-v64-ready .menu-mega-action {
    min-height: 38px;
    margin-top: 4px;
    padding: 9px 11px;
    font-size: .86rem;
  }
}

/* Rustige focuslaag achter een geopend desktopmenu. */
.menu-page-backdrop {
  display: none;
}

@media (min-width: 1101px) {
  .menu-page-backdrop {
    position: fixed;
    z-index: 999;
    top: var(--menu-backdrop-top,72px);
    right: 0;
    bottom: 0;
    left: 0;
    display: block;
    width: 100%;
    margin: 0;
    padding: 0;
    border: 0;
    outline: 0;
    background: rgba(12,38,51,.27);
    opacity: 0;
    visibility: hidden;
    pointer-events: none;
    cursor: pointer;
    -webkit-backdrop-filter: blur(4px) saturate(92%);
    backdrop-filter: blur(4px) saturate(92%);
    transition:
      opacity .26s cubic-bezier(.22,1,.36,1),
      visibility 0s linear .26s;
  }

  body.menu-page-dimmed .menu-page-backdrop {
    opacity: 1;
    visibility: visible;
    pointer-events: auto;
    transition-delay: 0s;
  }

  .site-header.menu-v64-ready .nav-dropdown,
  .site-header.menu-v64-ready .nav-group-endocrine .nav-dropdown,
  .site-header.menu-v64-ready .nav-group-immune .nav-dropdown,
  .site-header.menu-v64-ready .nav-group-more .nav-dropdown {
    animation-duration: .26s;
    animation-timing-function: cubic-bezier(.22,1,.36,1);
  }
}

@media (prefers-reduced-motion: reduce) {
  .menu-page-backdrop {
    transition: none;
  }
}