:root {
  --ink: #17324d;
  --muted: #5c7083;
  --blue: #087da7;
  --blue-dark: #075d81;
  --blue-pale: #edf8fc;
  --line: #dce8ee;
  --white: #fff;
  --shadow: 0 18px 48px rgba(17, 67, 91, .12);
}

* { box-sizing: border-box; }
html { scroll-behavior: smooth; }
body {
  margin: 0;
  color: var(--ink);
  background: #f7fbfd;
  font-family: Arial, Helvetica, sans-serif;
  line-height: 1.7;
}
a { color: var(--blue-dark); }
a:focus-visible { outline: 3px solid #f3bf45; outline-offset: 4px; border-radius: 4px; }
img { max-width: 100%; height: auto; }
.wrap { width: min(1120px, calc(100% - 40px)); margin-inline: auto; }

.site-header { background: var(--white); border-bottom: 1px solid var(--line); }
.header-inner {
  min-height: 84px;
  display: flex;
  align-items: center;
  justify-content: space-between;
  gap: 28px;
}
.brand { display: inline-flex; align-items: center; gap: 13px; color: var(--ink); text-decoration: none; }
.brand img { width: 46px; height: 46px; object-fit: contain; border-radius: 50%; }
.brand strong { display: block; font-size: 1.02rem; letter-spacing: .02em; }
.brand span span { display: block; color: var(--muted); font-size: .78rem; }
.site-nav { display: flex; flex-wrap: wrap; gap: 10px 22px; }
.site-nav a { color: var(--blue-dark); font-size: .9rem; font-weight: 700; text-decoration: none; }
.site-nav a:hover { text-decoration: underline; }

.page-hero {
  padding: 54px 0 48px;
  background: radial-gradient(circle at 15% 10%, rgba(50,187,219,.2), transparent 32%), linear-gradient(135deg,#eef9fc 0%,#f8fbfd 56%,#e8f4f8 100%);
  border-bottom: 1px solid var(--line);
}
.breadcrumbs { margin: 0 0 18px; color: var(--muted); font-size: .84rem; }
.breadcrumbs a { text-decoration: none; }
.eyebrow { margin: 0 0 10px; color: var(--blue); font-size: .76rem; font-weight: 800; letter-spacing: .13em; text-transform: uppercase; }
h1, h2, h3, h4 { color: var(--ink); line-height: 1.22; }
h1 { max-width: 900px; margin: 0; font-size: clamp(2.15rem,5vw,4rem); letter-spacing: -.04em; }
.page-intro { max-width: 780px; margin: 18px 0 0; color: var(--muted); font-size: 1.08rem; }

.article-shell {
  display: grid;
  grid-template-columns: minmax(0, 1fr) 275px;
  gap: 34px;
  align-items: start;
  padding: 52px 0 72px;
}
.article-card {
  min-width: 0;
  padding: clamp(24px,4vw,48px);
  border: 1px solid var(--line);
  border-radius: 22px;
  background: var(--white);
  box-shadow: 0 8px 26px rgba(17,67,91,.07);
}
.archive-note {
  margin: 0 0 30px;
  padding: 16px 18px;
  border-left: 4px solid var(--blue);
  border-radius: 0 10px 10px 0;
  background: var(--blue-pale);
  color: #31556a;
  font-size: .9rem;
}
.article-content { overflow-wrap: anywhere; }
.article-content h1 { font-size: 2rem; }
.article-content h2 { margin: 2.1em 0 .65em; font-size: 1.65rem; letter-spacing: -.02em; }
.article-content h3 { margin: 1.8em 0 .55em; font-size: 1.25rem; }
.article-content p { margin: 0 0 1.15em; }
.article-content ul, .article-content ol { padding-left: 1.35rem; }
.article-content li { margin-bottom: .45rem; }
.article-content::after { display: block; clear: both; content: ""; }
.article-content img { height: auto; max-width: 100%; border-radius: 12px; }
.article-image { display: block; width: min(44%,360px); margin-top: 8px; margin-bottom: 22px; border: 1px solid var(--line); background: var(--white); box-shadow: 0 10px 28px rgba(17,67,91,.09); object-fit: contain; }
.article-image-left { float: left; margin-right: 28px; margin-left: 0; }
.article-image-right { float: right; margin-right: 0; margin-left: 28px; }
.article-image-center { float: none; width: min(100%,720px); margin: 26px auto; }
.article-content h1, .article-content h2, .article-content h3 { clear: both; }
.article-content a { font-weight: 700; text-underline-offset: 2px; }
.article-content hr { margin: 34px 0; border: 0; border-top: 1px solid var(--line); }
.article-content > div:empty, .article-content p:empty { display: none; }

.side-card {
  padding: 22px;
  border: 1px solid var(--line);
  border-radius: 17px;
  background: var(--white);
}
.side-card + .side-card { margin-top: 16px; }
.side-card h2 { margin: 0 0 12px; font-size: 1.05rem; }
.side-card a { display: block; padding: 8px 0; border-bottom: 1px solid var(--line); font-size: .9rem; font-weight: 700; text-decoration: none; }
.side-card a:last-child { border-bottom: 0; }

.directory { padding: 52px 0 72px; }
.directory-grid { display: grid; grid-template-columns: repeat(3,minmax(0,1fr)); gap: 18px; }
.directory-card { padding: 24px; border: 1px solid var(--line); border-radius: 18px; background: var(--white); }
.directory-card h2 { margin: 0 0 14px; font-size: 1.18rem; }
.directory-card a { display: block; padding: 7px 0; font-weight: 700; text-decoration: none; }
.directory-card a:hover { text-decoration: underline; }

.contact-options { display: grid; grid-template-columns: repeat(2,minmax(0,1fr)); gap: 18px; margin: 28px 0 36px; }
.contact-option { display: flex; gap: 16px; align-items: flex-start; padding: 24px; border: 1px solid var(--line); border-radius: 18px; background: #f9fcfd; }
.contact-option h3 { margin: 0 0 6px; font-size: 1.12rem; }
.contact-option p { margin-bottom: 15px; }
.contact-option p a { font-size: 1.05rem; }
.contact-icon { display: grid; flex: 0 0 44px; width: 44px; height: 44px; place-items: center; border-radius: 50%; color: var(--white); background: var(--blue); font-size: 1.2rem; font-weight: 800; }
.contact-button { display: inline-block; padding: 10px 15px; border: 2px solid var(--blue-dark); border-radius: 9px; color: var(--white); background: var(--blue-dark); font-size: .9rem; font-weight: 800; line-height: 1.2; text-decoration: none; }
.contact-button:hover { background: #064c69; }
.contact-button-secondary { color: var(--blue-dark); background: var(--white); }
.contact-button-secondary:hover { background: var(--blue-pale); }
.contact-note { margin: 34px 0; padding: 22px 24px; border: 1px solid #cfe4ed; border-radius: 16px; background: var(--blue-pale); }
.contact-note h2 { margin: 0 0 10px; font-size: 1.25rem; }
.contact-note p { margin: 0; }
.contact-form-section { margin-bottom: 44px; }
.contact-form-section h2 { margin-top: 5px; }
.contact-form { position: relative; display: grid; gap: 20px; margin-top: 25px; padding: 26px; border: 1px solid var(--line); border-radius: 18px; background: #f9fcfd; }
.form-grid { display: grid; grid-template-columns: repeat(2,minmax(0,1fr)); gap: 18px; }
.form-field { display: grid; gap: 7px; }
.form-field label { color: var(--ink); font-size: .9rem; font-weight: 800; }
.form-field input, .form-field select, .form-field textarea { width: 100%; padding: 12px 13px; border: 1px solid #b9d1dc; border-radius: 9px; color: var(--ink); background: var(--white); font: inherit; line-height: 1.4; }
.form-field textarea { resize: vertical; min-height: 170px; }
.form-field input:focus, .form-field select:focus, .form-field textarea:focus { outline: 3px solid rgba(8,125,167,.18); border-color: var(--blue); }
.form-field small, .form-privacy { color: var(--muted); font-size: .78rem; }
.form-trap { position: absolute; left: -10000px; width: 1px; height: 1px; overflow: hidden; }
.form-consent { display: flex; gap: 10px; align-items: flex-start; color: #38596d; font-size: .86rem; }
.form-consent input { flex: 0 0 auto; width: 18px; height: 18px; margin-top: 4px; accent-color: var(--blue-dark); }
.form-submit { justify-self: start; padding: 13px 20px; border: 2px solid var(--blue-dark); border-radius: 9px; color: var(--white); background: var(--blue-dark); font: inherit; font-weight: 800; cursor: pointer; }
.form-submit:hover { background: #064c69; }
.form-privacy { margin: -6px 0 0!important; }
.form-result-page { display: grid; min-height: 100vh; padding: 30px; place-items: center; background: linear-gradient(135deg,#eef9fc,#f8fbfd); }
.form-result { width: min(100%,680px); padding: clamp(28px,5vw,52px); border: 1px solid var(--line); border-top: 6px solid var(--blue); border-radius: 20px; background: var(--white); box-shadow: var(--shadow); }
.form-result h1 { font-size: clamp(2rem,5vw,3.3rem); }
.form-result-error { border-top-color: #c07d28; }
.legal-content section { scroll-margin-top: 24px; }

.stem-cell-hero { padding: 48px 0 52px; border-bottom: 1px solid var(--line); background: radial-gradient(circle at 10% 12%,rgba(48,181,214,.2),transparent 30%),linear-gradient(135deg,#eef9fc,#f9fcfd 58%,#e8f4f8); }
.stem-cell-hero-grid { display: grid; grid-template-columns: minmax(0,1fr) minmax(340px,46%); gap: clamp(34px,5vw,66px); align-items: center; }
.stem-cell-hero h1 { max-width: 720px; }
.stem-cell-hero-media { margin: 0; overflow: hidden; border: 1px solid rgba(7,93,129,.18); border-radius: 24px; background: var(--white); box-shadow: var(--shadow); }
.stem-cell-hero-media img { display: block; width: 100%; height: auto; aspect-ratio: 3/2; object-fit: cover; }
.stem-cell-hero-media figcaption { padding: 12px 16px 14px; color: var(--muted); font-size: .78rem; line-height: 1.5; }
.article-meta { display: flex; flex-wrap: wrap; gap: 8px 20px; margin-top: 24px; color: var(--muted); font-size: .8rem; font-weight: 700; }
.article-meta span + span::before { margin-right: 20px; color: #92aab7; content: "•"; }
.stem-cell-layout { grid-template-columns: minmax(0,1fr) 285px; }
.stem-cell-article { padding: clamp(26px,4vw,52px); }
.stem-cell-article sup a { color: var(--blue-dark); text-decoration: none; }
.direct-answer { margin: 0 0 34px; padding: 24px 26px; border: 1px solid #cce5ee; border-left: 5px solid var(--blue); border-radius: 0 16px 16px 0; background: linear-gradient(135deg,#effafd,#fbfdfe); }
.direct-answer h2 { margin: 4px 0 12px; font-size: clamp(1.45rem,3vw,2rem); }
.direct-answer p:last-child { margin-bottom: 0; }
.article-toc { margin: 0 0 44px; padding: 24px 27px; border: 1px solid var(--line); border-radius: 17px; background: #fbfdfe; }
.article-toc strong { display: block; margin-bottom: 10px; font-size: 1.05rem; }
.article-toc ol { columns: 2; gap: 36px; margin: 0; padding-left: 1.35rem; }
.article-toc li { break-inside: avoid; margin: 7px 0; }
.article-toc a { font-weight: 700; text-decoration: none; }
.stem-section { scroll-margin-top: 24px; }
.stem-section + .stem-section, .legacy-callout + .stem-section { margin-top: 58px; }
.stem-section h2 { margin: 6px 0 18px; font-size: clamp(1.65rem,3vw,2.25rem); }
.stem-section h3 { margin-top: 28px; }
.stem-key-grid { display: grid; grid-template-columns: repeat(3,minmax(0,1fr)); gap: 14px; margin: 28px 0 36px; }
.stem-key-card { padding: 20px; border: 1px solid var(--line); border-radius: 16px; background: #fbfdfe; }
.stem-key-card span { display: inline-grid; width: 32px; height: 32px; place-items: center; border-radius: 50%; color: var(--white); background: var(--blue); font-size: .76rem; font-weight: 800; }
.stem-key-card h3 { margin: 12px 0 7px; font-size: 1.02rem; }
.stem-key-card p { margin: 0; color: var(--muted); font-size: .9rem; }
.gland-directory-grid { display: grid; grid-template-columns: repeat(2,minmax(0,1fr)); gap: 16px; margin: 28px 0 34px; }
.gland-directory-card { display: grid; gap: 7px; align-content: start; min-height: 145px; padding: 22px 23px; border: 1px solid var(--line); border-left: 4px solid #55afd0; border-radius: 0 17px 17px 0; color: var(--ink); background: #fbfdfe; text-decoration: none; transition: transform .18s ease, border-color .18s ease, box-shadow .18s ease; }
.gland-directory-card:hover { transform: translateY(-2px); border-color: #8bc8dc; box-shadow: 0 12px 28px rgba(17,67,91,.09); }
.gland-directory-card strong { color: var(--blue-dark); font-size: 1.02rem; line-height: 1.35; }
.gland-directory-card span { color: var(--muted); font-size: .9rem; line-height: 1.58; }
.gland-links a[aria-current="page"] { color: var(--ink); background: var(--blue-pale); }
.scientific-figure { width: min(100%,560px); margin: 32px auto; overflow: hidden; border: 1px solid var(--line); border-radius: 18px; background: var(--white); box-shadow: 0 12px 32px rgba(17,67,91,.08); }
.scientific-figure-wide { width: 100%; }
.scientific-figure img { display: block; float: none; width: 100%; height: auto; margin: 0; border: 0; border-radius: 0; object-fit: contain; }
.scientific-figure figcaption { padding: 13px 16px 15px; color: var(--muted); font-size: .82rem; line-height: 1.55; }
.stem-type-list { display: grid; gap: 13px; margin: 27px 0 32px; }
.stem-type-list section { padding: 21px 23px; border: 1px solid var(--line); border-left: 4px solid #55afd0; border-radius: 0 15px 15px 0; background: #fbfdfe; }
.stem-type-list h3 { margin: 0 0 8px; font-size: 1.12rem; }
.stem-type-list p { margin: 0; }
.potency-table { overflow-x: auto; margin: 30px 0; border: 1px solid var(--line); border-radius: 16px; }
.potency-table table { width: 100%; border-collapse: collapse; background: var(--white); }
.potency-table th, .potency-table td { padding: 14px 16px; border-bottom: 1px solid var(--line); text-align: left; vertical-align: top; }
.potency-table thead th { color: var(--blue-dark); background: var(--blue-pale); font-size: .82rem; text-transform: uppercase; letter-spacing: .04em; }
.potency-table tbody th { white-space: nowrap; color: var(--ink); }
.potency-table tr:last-child th, .potency-table tr:last-child td { border-bottom: 0; }
.treatment-status { margin: 25px 0; padding: 25px 27px; border: 1px solid #bddfcd; border-radius: 18px; background: linear-gradient(145deg,#f1fbf5,#ffffff); }
.treatment-status > span, .evidence-card > span { display: inline-block; padding: 5px 9px; border-radius: 999px; color: #236744; background: #dff4e7; font-size: .72rem; font-weight: 800; letter-spacing: .05em; text-transform: uppercase; }
.treatment-status h3 { margin: 11px 0 10px; }
.treatment-status p:last-child { margin-bottom: 0; }
.proven-eu { border-color: #c9ddea; background: linear-gradient(145deg,#eef8fc,#ffffff); }
.proven-eu > span { color: var(--blue-dark); background: #dceff6; }
.evidence-grid { display: grid; grid-template-columns: repeat(2,minmax(0,1fr)); gap: 17px; margin: 27px 0 32px; }
.evidence-card { padding: 23px; border: 1px solid var(--line); border-radius: 18px; background: #fbfdfe; }
.evidence-card > span { color: #745518; background: #fbefca; }
.evidence-card h3 { margin: 12px 0 9px; }
.evidence-card p { margin: 0; }
.research-list { display: grid; gap: 8px; padding-left: 1.25rem; }
.research-list li { padding-left: 5px; }
.legacy-callout { margin: 58px 0; padding: 29px 31px; border: 1px solid #d4e5ec; border-radius: 20px; background: radial-gradient(circle at 96% 6%,rgba(71,179,207,.18),transparent 28%),linear-gradient(145deg,#f1fafd,#ffffff); }
.legacy-callout h2 { margin: 5px 0 13px; font-size: clamp(1.6rem,3vw,2.15rem); }
.legacy-callout p:last-child { margin-bottom: 0; }
.risk-grid { display: grid; grid-template-columns: repeat(2,minmax(0,1fr)); gap: 13px; margin: 26px 0; }
.risk-grid div { padding: 20px 21px; border: 1px solid var(--line); border-radius: 15px; background: #fbfdfe; }
.risk-grid h3 { margin: 0 0 7px; font-size: 1.02rem; }
.risk-grid p { margin: 0; color: var(--muted); font-size: .9rem; }
.warning-panel { margin-top: 30px; padding: 24px 26px; border: 1px solid #ebd3aa; border-left: 5px solid #d69b33; border-radius: 0 17px 17px 0; background: #fffaf0; }
.warning-panel h3 { margin: 0 0 11px; }
.warning-panel p:last-child { margin-bottom: 0; }
.history-timeline { position: relative; display: grid; gap: 0; margin: 29px 0 0; padding: 0; list-style: none; }
.history-timeline::before { position: absolute; top: 12px; bottom: 12px; left: 73px; width: 2px; background: #c7e0e9; content: ""; }
.history-timeline li { position: relative; display: grid; grid-template-columns: 58px minmax(0,1fr); gap: 32px; padding: 0 0 24px; }
.history-timeline li::before { position: absolute; top: 7px; left: 67px; width: 14px; height: 14px; border: 3px solid var(--white); border-radius: 50%; background: var(--blue); box-shadow: 0 0 0 1px #8fc9dc; content: ""; }
.history-timeline strong { color: var(--blue-dark); }
.history-timeline span { color: #415f72; }
.faq-list details { margin: 9px 0; border: 1px solid var(--line); border-radius: 13px; background: var(--white); }
.faq-list summary { cursor: pointer; padding: 15px 17px; color: var(--ink); font-weight: 800; }
.faq-list details p { margin: 0; padding: 0 17px 17px; }
.sources-section { padding-top: 2px; }
.sources-list { padding-left: 1.35rem; }
.sources-list li { margin-bottom: 12px; padding-left: 5px; }
.sources-list a { overflow-wrap: anywhere; }
.source-note { margin-top: 28px; padding: 20px 22px; border-radius: 15px; background: var(--blue-pale); }
.source-note p { margin: 0; }
.stem-cell-aside { position: sticky; top: 18px; }
.trust-card p { margin: 0; color: var(--muted); font-size: .85rem; }

.site-footer { padding: 28px 0 36px; color: var(--muted); font-size: .88rem; }
.footer-inner { display: flex; justify-content: space-between; gap: 20px; padding-top: 24px; border-top: 1px solid var(--line); }

@media (max-width: 880px) {
  .header-inner, .footer-inner { align-items: flex-start; flex-direction: column; padding-top: 18px; padding-bottom: 18px; }
  .article-shell { grid-template-columns: 1fr; }
  .article-aside { display: grid; grid-template-columns: repeat(2,minmax(0,1fr)); gap: 16px; }
  .side-card + .side-card { margin-top: 0; }
  .directory-grid { grid-template-columns: repeat(2,minmax(0,1fr)); }
  .stem-cell-hero-grid { grid-template-columns: 1fr; }
  .stem-cell-hero-copy { max-width: 820px; }
  .stem-cell-hero-media { width: min(100%,720px); }
  .stem-cell-aside { position: static; }
}
@media (max-width: 580px) {
  .wrap { width: min(100% - 28px,1120px); }
  .site-nav { gap: 8px 16px; }
  .page-hero { padding: 40px 0 38px; }
  .article-shell { padding-top: 34px; }
  .article-card { padding: 22px; }
  .article-image, .article-image-left, .article-image-right, .article-image-center { float: none; width: min(100%,520px); margin: 24px auto; }
  .article-aside, .directory-grid, .contact-options, .form-grid { grid-template-columns: 1fr; }
  .stem-cell-hero { padding: 36px 0 40px; }
  .stem-cell-hero-grid { gap: 28px; }
  .article-meta { display: block; }
  .article-meta span { display: block; }
  .article-meta span + span { margin-top: 4px; }
  .article-meta span + span::before { display: none; }
  .article-toc ol { columns: 1; }
  .stem-key-grid, .evidence-grid, .risk-grid, .gland-directory-grid { grid-template-columns: 1fr; }
  .stem-cell-article { padding: 22px; }
  .direct-answer, .legacy-callout { padding: 21px; }
  .history-timeline::before { left: 62px; }
  .history-timeline li { grid-template-columns: 48px minmax(0,1fr); gap: 28px; }
  .history-timeline li::before { left: 56px; }
}